BOEHRINGER INGELHEIM INTERNATIONAL GMBH;VITAE PHARMACEUTICALS, INC.
发明人:
FRANK HIMMELSBACH,HERBERT NAR,LINGHANG ZHUANG,MATTHIAS ECKHARDT,STEFAN PETERS
申请号:
BR112012010792
公开号:
BR112012010792A2
申请日:
2010.11.05
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11beta-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.