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ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF HEXAHYDROINDENOPYRIDINE AND OCTAHYDROBENZOQUINOLINE
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;VITAE PHARMACEUTICALS, INC.; INC.;VITAE PHARMACEUTICALS
发明人:
ECKHARDT, MATTHIAS,PETERS, STEFAN,NAR, HERBERT,HIMMELSBACH, FRANK,ZHUANG, LINGHANG
申请号:
SG2012019006
公开号:
SG179569A1
申请日:
2010.11.05
申请国别(地区):
SG
年份:
2012
代理人:
摘要:
The present invention relates to compounds defined by formula I, wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
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中国工程科技知识中心
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