ABRECHT HELGE,MARCHAND MARTINE,MATHY NATHALIE LOUISE,PERMANNE PHILIPPE JEAN GERVAIS GHISLAIN,VOSS GERALD HERMANN,DELCHAMBRE MARTINE
申请号：
IN621/KOLNP/2007
公开号：
IN253465B
申请日:
2007.02.20
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
This invention relates to novel HIV polypeptide and polynucleotide fusions of Gag, Pol and Nef which are useful in immunogenic compositions and vaccines. The invention relates in particular to a polypeptide which comprises Nef or an immunogenic fragment or derivative thereof, p17 Gag and p24 Gag or immunogenic fragments or derivatives thereof, wherein there is at least one HIV antigen or immunogenic fragment between p17 Gag and p24 Gag, the polypeptide further comprising RT or an immunogenic fragment or derivative thereof, and wherein the immunogenic fragments or derivatives remain capable of raising an immune response against the native antigen. Figure 20.
