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Vaccine for prevention and treatment of HIV-infection
专利权人:
GlaxoSmithKline Biologicals sa
发明人:
Marchand, Martine,Permanne, Philippe Jean Gervais Ghislain,Mathy, Nathalie Louise,Delchambre, Martine,Voss, Gerald Hermann,Abrecht, Helge
申请号:
AU2005268856
公开号:
AU2005268856B2
申请日:
2005.08.03
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
This invention relates to HIV polypeptide and polynucleotide fusions of Gag, Pol and Nef which are useful in immunogenic compositions and vaccines. The invention relates in particular to a polypeptide which comprises Nef or an immunogenic fragment thereof, and p17 Gag and/or p24 Gag or immunogenic fragments thereof, wherein when both p17 and p24 Gag are present there is at least one HIV antigen or immunogenic fragment between them. The polypeptide may also comprise Pol or RT or an immunogenic fragment thereof.
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