The bright Department Off whats of this Hair can exempt from epidemic disease original Group conjunction objects and the new Ying HIV polypeptides of vaccine with what and the polynucleotides of Gag, Pol With Nef melt conjunction Body. For having Body, the bright Department Off whats one of this Hair include its immunogen fragment of Nef or one and the polypeptide of p17 Gag and/or p24 Gag or its immunogen fragment, and wherein When p17 and p24 Gag Two persons all deposit in Time, the Inter of its Men is at least deposited in a Seed HIV antigens or immunogen fragment. The polypeptides also may include Pol or RT or its immunogen fragment.本發明係關於可用於免疫原組合物及疫苗的新穎HIV多肽及Gag、Pol與Nef之多核苷酸融合體。具體而言,本發明係關於一包含Nef或一其免疫原片段及p17 Gag及/或p24 Gag或其免疫原片段之多肽,其中當p17及p24 Gag兩者皆存在時,它們之間至少存在一種HIV抗原或免疫原片段。該多肽亦可包含Pol或RT或一其免疫原片段。
