KILLEEN, KEVIN, P.,GRIFFIN, THOMAS, J., IV,THANAWASTIEN, ANN
申请号：
EP10816102
公开号：
EP2473188A4
申请日:
2010.09.09
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention relates to immunogenic compositions containing an antigen of interest entrapped with a crosslinked carrier protein matrix, methods of making such vaccines, and methods of vaccine administration, wherein the immunogenicity of the protein matrix, and hence its effectiveness as a vaccine, is improved by controlling or selecting the particle size of the protein matrix particles to eliminate low molecular weight particles, e.g., less than 100 nm in diameter.
