KILLEEN KEVIN P,THANAWASTEIN ANN,GRIFFIN THOMAS J IV
申请号：
ZA201201714
公开号：
ZA201201714B
申请日:
2012.03.08
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
The present invention relates to immunogenic compositions containing an antigen of interest entrapped with a crosslinked carrier protein matrix, methods of making such vaccines, and methods of vaccine administration, wherein the immunogenicity of the protein matrix, and hence its effectiveness as a vaccine, is improved by controlling or selecting the particle size of the protein matrix particles to eliminate low molecular weight particles, e.g., less than 100 nm in diameter.
