Thomas J. Griffin, IV;Ann Thanawastien;Kevin P. Killen
发明人:
Kevin P. Killen,Thomas J. Griffin, IV,Ann Thanawastien
申请号：
US13394147
公开号：
US20120231086A1
申请日:
2010.09.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to immunogenic compositions containing an antigen of interest entrapped with a crosslinked carrier protein matrix, methods of making such vaccines, and methods of vaccine administration, wherein the immunogenicity of the protein matrix, and hence its effectiveness as a vaccine, is improved by controlling or selecting the particle size of the protein matrix particles to eliminate low molecular weight particles, e.g., less than 100 nm in diameter.
