FIELD: chemistry.SUBSTANCE: invention relates to a compound of (I)where R1 and R2 formula independently selected from H, alkyl, haloalkyl, alkoxyalkyl, haloalkoxyalkyl, cycloalkyl, cycloalkylalkyl, halocycloalkyl, halocycloalkylalkyl, substituted aryl, substituted arylalkyl, substituted heterocycloalkyl, substituted heterocycloalkylalkyl, substituted heteroaryl, substituted heteroarylalkyl, substituted aminocarbonyl, alkoxycarbonyl, haloalkoxycarbonyl and carboxy, wherein the substituted aryl, substituted arylalkyl, substituted heterocycloalkyl, substituted heterocycloalkylalkyl, substituted heteroaryl and substituted heteroarylalkyl are substituted with R14, R15 and R16, and wherein the substituted aminocarbonyl on the nitrogen atom is substituted with from one to two substituents independently selected from H, alkyl, cycloalkyl, haloalkyl, alkylcycloalkyl, cycloalkylalkyl, alkylcycloalkylalkyl, hydroxyalkyl and alkoxyalkyl； R3 is pyrrolidinyl, substituted [1,2,4]-oxadiazolyl, oxazolyl, substituted thiazolyl, substituted [1,2,4]thiadiazol-5-yl or pyrimidinyl, wherein the substituted with [1,2,4] thiadiazol-5-yl substituted [1,2,4]-oxadiazolyl and substituted thiazolyl are substituted with R17； R4 is H or alkyl； R5 and R6 are independently selected from H, alkyl and cycloalkyl； R7 is H, alkyl or cycloalkyl； A represents NR8 or CR9R10； E is CR12R13； R8 is selected from H, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, cycloalkylalkyl or halocycloalkylalkyl； R9 and R12 together with the carbon atoms to which they are attached, form a substituted cycloalkyl, substituted cycloalkenyl, substituted aryl, substituted heterocycloalkyl or substituted heteroaryl, wherein the substituted cycloalkyl, substituted cycloalkenyl, substituted aryl, substituted heterocycloalkyl, and substituted heteroaryl are substituted with R20 and can be further substituted with R21, where in the case when R9 and R12 together with the carbon atoms to which they are attached, form a substituted aryl
