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SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND USING THEM
专利权人:
BAJER INTELLEKTUEHL PROPERTI GMBKH;BAJER INTELLEKTUEHL' PROPERTI GMBKH
发明人:
LAMPE Tomas (DE),ЛАМПЕ Томас (DE),KhAN Mikhael' (DE),ХАН Михаель (DE),STASh Jokhannes-Peter (DE),СТАШ Йоханнес-Петер (DE),ShLEMMER Karl-Khajnts (DE),ШЛЕММЕР Карл-Хайнц (DE),VUNDER Frank (DE),ВУНДЕР Фр,LAMPE TOMAS,ЛАМПЕ Томас,KHAN MIKHAEL,ХАН Михаель,STASH JOKHANNES-PETER,СТАШ Йоханнес-Петер,SHLEMMER KARL-KHAJNTS,ШЛЕММЕР Карл-Хайнц,VUNDER FRANK,ВУНДЕР Франк,EHL SHEJKH SHERIF,ЭЛЬ ШЕЙХ Шериф,LI FOLKKH
申请号:
RU2012121577/04
公开号:
RU0002553263C2
申请日:
2010.10.21
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to 3-phenylpropionic acid derivatives of formulawherein R1A represents hydrogen, methyl, ethyl, cyclopropyl or cyclobutyl, R1B is hydrogen or methyl, R2A represents hydrogen, methyl, trifluoromethyl, ethyl or n-propyl, R2B is hydrogen or methyl or R1A and R2A are combined together, and in a combination to carbon atoms to which they are attached, form a cyclopropyl ring of formulawherein R1B and R2B have the values as specified above, or R2A and R2B are combined together, and in a combination to a carbon atom, to which they are attached, form a cyclic group of formula orwherein n means a number 1 or 2, R3 is hydrogen, fluorine or methyl, R4 represents hydrogen, fluorine, chlorine or a cyanogroup, R5A represents methyl, R5B is trifluoromethyl or R5A and R5B are combined together, and in a combination to a carbon atom, to which they are attached, form a difluorosubstituted cycloalkyl ring of formula orR6 represents chlorine, alkyl with 1-4 carbon atoms, alkenyl with 2-4 carbon atoms, cyclopropyl or cyclobutyl; alkyl with 1-4 carbon atoms and alkenyl with 2-4 carbon atoms can contain up to three fluorine atoms, cyclopropyl and cyclobutyl up to three fluorine atoms as substitutes, and R7 represents hydrogen, fluorine, chlorine, methyl or a methoxy group. The invention also refers to a therapeutic agent containing the above compounds and to a method for producing the compounds of formula (I).EFFECT: compounds of formula (I) activate the form of soluble haem-free guanylate cyclase and are applicable in the method of treating and/or preventing cardiac failure, angina, hypertension, pulmonary hypertension, ischemia, vascular diseases, disturbed microcirculation, thromboembolic diseases and arterial sclerosis.6 cl, 4 tbl, 113 exИзобретение относится к производным 3-фенилпропионовой кислоты формулы (I), где R1A представляет собой водород, метил, этил, циклопропил или циклобутил, R1B является водородом или метилом,
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