오네일 제임스 덴넨,바마트 마이클 케이.,본 볼스텔 리드 더블유.,샤르마 샤리니,아루드찬드란 라마찬드란
申请号：
KR1020107021875
公开号：
KR1016779440000B1
申请日:
2009.03.13
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
By administering a compound of formula I, or a pharmaceutically acceptable salt thereof, the uric acid in the mammal is reduced or increased uric acid emissions: In Formula (I), m is 0, 1, 2, 3 or 4； n is 0 or 1； m + n is 4 or less； t is 0 or 1； q is 0 or 1； r is 0, 1 or 2； R 6 is hydrogen, methyl or ethyl and R 12 is hydrogen or methyl, or R 6 is hydroxy and R 12 is hydrogen, R 6 is O and R 12 is absent, or R 6 and R 12 together are -CH 2 CH 2 -. R <； 7 >； is hydrogen or alkyl having 1 to 3 carbon atoms. R 8 and R 9 is alkyl having 1 to 3 carbon atoms and the other is hydrogen or alkyl having 1 to 3 carbon atoms. R 10 is hydrogen, halo, alkyl having 1 to 3 carbon atoms or alkoxy having 1 to 3 carbon atoms. X is C (O), r is 0 and t is 0； X is alkyl of NH (R 11), where R 11 is hydrogen or from one to three carbon atoms. A is phenyl unsubstituted or substituted by one or two groups selected from halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy； Or a 5 or 6 membered heteroaromatic ring having one or two ring heteroatoms selected from N, S and O, wherein said heteroaromatic ring is covalently bonded to the remainder of the compound of formula I by a ring carbon, ； Or cycloalkyl having 3 to 6 ring carbon atoms wherein said cycloalkyl is unsubstituted or where one or two ring carbons are independently mono-substituted by methyl or ethyl. The uricosamine-lowering effect of the compound of formula (I) increases the level of uric acid that does not meet the customary justification of diagnosis of gout, hyperlipidemia, hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, cardiovascular disease For example, in the treatment or prevention of a variety of diseases including hypertension, hypertension, risk of onset, tumor dissolution syndrome, cognitive impairment and premature hypertension.다음의 화학식 Ⅰ의 화합물 또는 그의 제약학적으로 허용가능한 염을 투여 함으로써, 포유동물 대상의 요산은 감소되거나 요산 배출이 증가된다:상기 화학식 Ⅰ에서, m은 0,1,2,3 또는 4이고； n은 0 또는 1이며； m+n은
