The present invention pertains to a compound having an exceptional effect for inhibiting retinoic-acid-receptor-related orphan receptors [gamma]t, or a pharmacologically acceptable salt thereof. A compound represented by general formula (I) (in the formula, R1 represents a C1-C6 alkyl group, a C3-C6 cycloalkyl group, or a phenyl group R2 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like R3 represents a hydrogen atom, a C2-C7 carboxyalkyl group, or a hydroxyl group R4 represents a halogen atom or a C1-C6 alkyl group R5 represents a hydrogen atom or a C1-C6 alkyl group R6 represents a hydrogen atom, a halogen atom, or a C1-C6 alkyl group Q1 represents a nitrogen atom or a group represented by the formula =CH- Q2 represents a nitrogen atom or a group represented by the formula =CH- a group represented by the formula -U-T- represents a group represented by the formula -CH2-CH2-, or the like Y represents a methylene group or an oxygen atom V represents a nitrogen atom or a group represented by the formula =C(R7)- R7 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like E represents a piperidine-1-yl group, piperidine-4-yl group, or 1,2,3,6-tetrahydropyridine-4-yl group optionally substituted independently by from one to four groups selected from substituent group A, or the like substituent group A includes C1-C6 alkyl groups, C1-C6 alkyl halide groups, groups represented by the formula -L-R8, and the like L represents a carbonyl group, an oxalyl group, or the like R8 represents a C1-C6 alkyl group, a C1-C6 hydroxyalkyl group, a mono-C1-C6 alkylamino group, or the like), or a pharmacologically acceptable salt thereof.本發明之課題係關於具有優異視網酸受體關聯孤兒受體γt抑制作用的化合物或其藥學上可容許的鹽。本發明之解決手段係一種通式(I)所表示的化合物或其藥學上可容許的鹽:[式中,R1為C1-C6烷基、C3-C6環烷基、苯基;R2為氫原子、鹵素原子、C1-C6烷基等;R3為氫原子、C2-C7羧基烷基、羥基;R4為鹵素原子、C1-C6烷基;R5為氫原子、C1-C6烷基;R6為氫原子、鹵素原子、C1-C6烷基;Q1為氮原子、式=CH-所表示的基;Q2為氮原子、式=CH-所表示的基;式-U-T-所表示的基為式-CH2-CH2-所表示的基等;Y為亞甲基、氧原子;V為氮原子、式=C(R7)-所表示的基;R7為氫原子、鹵素原子、C1-C6烷
