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環狀胺化合物
专利权人:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
HASUOKA, ATSUSHI,莲冈淳,蓮岡淳
申请号:
TW097129774
公开号:
TWI418543B
申请日:
2008.08.06
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
A compound represented by the formula (I)wherein R1is a hydrogen atom, a halogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom or a group via a sulfur atom; R2is a hydrogen atom, a halogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom or a group via a sulfur atom; R3is an electron-withdrawing group; R4is a hydrogen atom, a halogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom or a group via a sulfur atom; R5is a hydrogen atom, a halogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom or a group via a sulfur atom; R6is a hydrogen atom, a halogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom or a group via a sulfur atom; R7is an alkyl group optionally having substituent(s) or an aralkyl group optionally having substituent(s); R8is a hydrogen atom, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s) or a cycloalkyl group optionally having substituent(s); R9is a group via an oxygen atom; and Ring A is a 5- or 6-membered ring optionally further having substituent(s) (in this case, Ring A may be a 5- or 6-membered ring forming a spiro bond with C3-6cycloalkane), or a salt thereof has a superior androgen receptor modulating action.下式(I)所示之化合物或其鹽具有優越之雄激素受體調節作用:式中R1為氫原子、鹵原子、經由碳原子之基團、經由氮原子之基團、經由氧原子之基團或經由硫原子之基團;R2為氫原子、鹵原子、經由碳原子之基團、經由氮原子之基團、經由氧原子之基團或經由硫原子之基團;R3為吸電子基團;R4為氫原子、鹵原子、經由碳原子之基團、經由氮原子之基團、經由氧原子之基團或經由硫原子之基團;R5為氫原子、鹵原子、經由碳原子之基團、經由氮原子之基團、經由氧原子之基團或經由硫原子之基團;R6為氫原子、鹵原子、經由碳原子之基團、經由氮原子之基團、經由氧原子之基團或經由硫原子之基團;R7為視需要具有取代基之烷基或視需要具有取代基之芳烷基;R8為氫原子、視需要具有取代基之烷基、視需要具有取代基之烯基或視需要具有取代基之環烷基;R9為經由氧原子之基團;及A環為視需要進一步具有取代基之5或6員環(於此情形下,A環可為與C3-6環烷形成螺鍵之5或6員環)。
来源网站:
中国工程科技知识中心
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