Iversen, Partrick L.,Moulton, Hong M.,Nelson, Michelle H.,Kroeker, Andrew D.,Stein, David A.
申请号：
AU2011200720
公开号：
AU2011200720B2
申请日:
2011.02.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011200720B220121108.pdf#####CANRPortbFDCC\AAR\347 12_I DOC-IM)02/2011 - 58 ABSTRACT Compositions and methods for enhancing delivery of molecule, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a 5 nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
