Patrick L. Iversen,Hong M. Moulton,Michelle H. Nelson,David A. Stein,Andrew D. Kroeker
申请号：
US16379046
公开号：
US20200016280A1
申请日:
2019.04.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
