Andrew D. Kroeker;Patrick L. Iversen;David A. Stein;Hong M. Moulton;Michelle H. Nelson
发明人:
Patrick L. Iversen,Hong M. Moulton,Michelle H. Nelson,Andrew D. Kroeker,David A. Stein
申请号：
US12265499
公开号：
US09572899B2
申请日:
2008.11.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
