IVERSEN, PATRICK, L.,MOULTON, HONG M.,NELSON, MICHELLE, H.,KROEKER, ANDREW, D.,STEIN, DAVID, A.
申请号：
DK10174646
公开号：
DK2351844T3
申请日:
2004.04.29
申请国别(地区):
DK
年份:
2014
代理人:
摘要：
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
