PROCÉDÉ DE PRÉPARATION DU CHLORHYDRATE DE 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHÉNYLAMINO)-7-MÉTHOXYQUINAZOLIN-6-YLOXY)PIPÉRIDIN-1-YL)-PROP-2-ÈN-1-ONE ET INTERMÉDIAIRES UTILISÉS AU COURS DUDIT PROCÉDÉ DE PRÉPARATION

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专利权人:

LTD.;HANMI SCIENCE CO.

发明人:

BANG, KEUK CHAN,MOON, YOUNG HO,CHANG, YOUNG KIL

申请号：

EP12838558

公开号：

EP2763981A4

申请日:

2012.10.05

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride, which selectively and effectively inhibits the growth of cancer cells induced by over-expression of an epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutation of a tyrosine kinase, and intermediates used therein.

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中国工程科技知识中心

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