AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES;THE GOVERNMENT OF THE UNITED STATES OF AMERICA
发明人:
PASTAN, IRA H.,ONDA, MASANORI,NAGATA, SATOSHI,FITZGERALD, DAVID,KREITMAN, ROBERT,LEE, BYUNGKOOK
申请号：
CA2616987
公开号：
CA2616987C
申请日:
2006.07.25
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides mutated Pseudomonas exotoxins (PE) that have reducedimmunogenicity compared to PEs containing the native sequence. The PEs of theinvention have one or more individual mutations of positions of the nativesequence of PE that reduce antibody binding to one or more PE epitopes.Nucleic acids encoding the mutated PEs, chimeric molecules comprising them,compositions comprising the chimeric molecules and methods of using them, arealso provided.
