as represented by the Secretary of Health and Human Services National Institutes of Health;The Government of The United States of America
发明人:
Lee, Byungkook,Nagata, Satoshi,Kreitman, Robert,Pastan, Ira H.,Fitzgerald, David,Onda, Masanori
申请号：
AU2006275865
公开号：
AU2006275865B2
申请日:
2006.07.25
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention provides mutated Pseudomonas exotoxins (PE) that have reducedimmunogenicity compared to PEs containing the native sequence. The PEs of theinvention have one or more individual mutations of positions of the native sequenceof PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encodingthe mutated PEs, chimeric molecules comprising them, compositions comprisingthe chimeric molecules and methods of using them, are also provided.
