Ira H. Pastan;Masanori Onda;Satoshi Nagata;David Fitzgerald;Robert Kreitman;Byungkook Lee
发明人:
Ira H. Pastan,Masanori Onda,Satoshi Nagata,David Fitzgerald,Robert Kreitman,Byungkook Lee
申请号：
US11997202
公开号：
US08907060B2
申请日:
2006.07.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides mutated Pseudomonas exotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided.
