DIGIANDOMENICO ANTONIO,WARRENER PAUL G.,STOVER CHARLES K.,SELLMAN BRET,GUILLARD SANDRINE,MINTER RALPH,RUST STEVEN,TOMICH MLADEN
申请号：
NZ61826612
公开号：
NZ618266A
申请日:
2012.06.08
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an isolated antibody or antigen-binding fragment thereof which specifically binds to Pseudomonas Psl polysaccharide, wherein the antibody or antigen-binding fragment thereof promotes opsonophagocytic killing (OPK) of P. aeruginosa, and wherein the isolated antibody or antigen-binding fragment thereof specifically binds to the same Pseudomonas Psl epitope as an antibody or antigen-binding fragment thereof comprising the heavy chain variable region (VH) and the light chain variable region (VL) of WapR-004RAD. Also disclosed is an isolated antibody or antigen-binding fragment thereof which specifically binds to Pseudomonas Psl polysaccharide, comprising a set of complementarity determining regions (CDRs) VHCDR1, VHCDR2, VHCDR3, VLCDR1, VLCDR2 and VLCDR3 having the sequences of PYYWT, YIHSSGYTDYNPSLKS, ADWDLLHALDI, RASQSIRSHLN, GASNLQS and YSFPLT.
