Disclosed is an isolated antibody or antigen-binding fragment thereof that specifically binds human Tie2 and blocks the interaction between Tie2 and all four of Ang1, Ang2, Ang3 and Ang4, wherein the antibody or antigen-binding fragment interacts with amino acids 96-106 of SEQ ID NO:7, amino acids 139-152 of SEQ ID NO:7 and amino acids 166-175 of SEQ ID NO:7, as determined by hydrogen/deuterium exchange, and comprises the heavy and light chain complementarity determining regions (CDRs) of the antibody produced from a cell line deposited with the American Type Culture Collection under accession number PTA-12295. Also disclosed is the use of the above-described antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting the growth of a tumour in a patient.
