High affinity human antibodies to human angiopoietin-2

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专利权人:

REGENERON PHARMACEUTICALS INC.

发明人:

DALY CHRISTOPHER,THURSTON GAVIN

申请号：

NZ59820210

公开号：

NZ598202A

申请日:

2010.07.27

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

598202 Disclosed is an isolated antibody or antigen-binding fragment thereof that binds to the same epitope on hAng-2 as an antibody which comprises the complementarity determining regions (CDRs) of a heavy chain variable region (HCVR) having the amino acid sequence of SEQ ID NO:18, and the CDRs of a light chain variable region (LCVR) having the amino acid of SEQ ID NO:20. Wherein SEQ ID NO:18 is: EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYDIHWVRQATGKGLEWVSAIGPAGDTYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGLITFGGLIAPFDYWGQGTLVTVSS And SEQ ID NO:20 is: EIVLTQSPGTLSLSPGERATLSCRASQSVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYDNSQTFGQGTKVEIK

来源网站：

中国工程科技知识中心

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