St2l antagonists and methods of use

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专利权人:

JANSSEN BIOTECH INC.

发明人:

Duffy, Karen,Healy, Catherine,Lamb, Roberta,Malaviya, Ravi,Pratta, Michael,Fursov, Natalie,Luo, Jinquan,Naso, Michael,Tornetta, Mark,Wheeler, John,Wu, Sheng-Jiun,Hall, Leroy

申请号：

NZ72991313

公开号：

NZ729913A

申请日:

2013.04.29

申请国别(地区):

NZ

年份:

2018

代理人:

摘要：

The present invention relates to an isolated human or human-adapted antibody antagonist or fragment thereof that specifically binds Domain I (SEQ ID NO: 9) of human interleukin-1 receptor like 1 (ST2L), comprising a heavy chain complementarity determining region (HCDR) 1 (HCDR1), a HCDR 2 (HCDR2), a HCDR 3 (HCDR3), a light chain complementarity determining region (LCDR) 1 (LCDR1), a LCDR 2 (LCDR2), and a LCDR 3 (LCDR3), wherein a) the HCDR1 comprises SEQ IDNO: 96； b) the HCDR2 comprises SEQ ID NO: 110； c) the HCDR3 comprises SEQ ID NO: 84； d) the LCDR1 comprises SEQ ID NO: 130； e) the LCDR2 comprises SEQ ID NO: 90； and f) the LCDR3 comprises SEQ ID NO； 131.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/