The Government of the United States of America; as represented by The Secretary of Health and Human Services National Institutes of Health
发明人:
Pastan, Ira H.,Onda, Masanori,Nagata, Satoshi,Fitzgerald, David,Kreitman, Robert,Lee, Byungkook
申请号：
AU2016202754
公开号：
AU2016202754A1
申请日:
2016.04.29
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016202754A120160526.pdf#####2016202754 MUTATED PSEUDOMONAS EXOTOXINS WITH REDUCED ANTIGENICITY Abstract: The invention provides mutated Pseudomonas exotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided.
