Holbrook Kohrt,Roch Houot,Ronald Levy,Arash Ash Alizadeh,Matthew J. Goldstein,James Torchia
申请号：
US13513523
公开号：
US20120321646A1
申请日:
2010.12.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies, thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule.
