KOHRT HOLBROOK,HOUOT ROCH,LEVY RONALD,ALIZADEH ARASH ASH,GOLDSTEIN MATTHEW J,TORCHIA JAMES
申请号：
IN5576/CHENP/2012
公开号：
IN2012CN05576A
申请日:
2012.06.26
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule.
