The Board of Trustees of the Leland Stanford Junior University
发明人:
KOHRT, Holbrook,HOUOT, Roch,LEVY, Ronald,ALIZADEH, Arash Ash,GOLDSTEIN, Matthew J.,TORCHIA, James
申请号：
AU2016201190
公开号：
AU2016201190A1
申请日:
2016.02.25
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016201190A120160317.pdf#####ABSTRACT Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies, thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule.
