THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
KOHRT, HOLBROOK,HOUOT, ROCH,LEVY, RONALD,ALIZADEH, ARASH ASH,GOLDSTEIN, MATTHEW J.,TORCHIA, JAMES
申请号:
SG2012041505
公开号:
SG181533A1
申请日:
2010.12.07
申请国别(地区):
SG
年份:
2012
代理人:
摘要:
Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies, thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule.