Involving hexahydrophenylpyridine and octahydrophenyldimethylbenzene derivatives (I),Among them, R1 refers to phenyl, northwest non fluorine, pyridinol, furan, endrin, etc.； R2 refers to h, halogen, cyanogen, nitric acid, ammonia, etc.； R3 and R4 refer to h, halogen, C1-C3 tar, trifluoroide, hydroxyl, C1-C3 tar, etc.； m refers to 0 or 1. - 1-toluene-toluene-toluene-toluene-toluene (toluene-toluene-toluene-1-toluene-toluene-toluene-4,4 a, 5,6,10b octahydro benzo [F] quinolina-8-carboxilico,There are others A pharmaceutical composer was also mentioned These compounds inhibit 11 - β - hydroxycholesterol dehydrogenase-1 (hsd-1) and can be used to treat metabolic disorders such as type 2 diabetes mellitus, obesity and degreasing.REFERIDA A UN DERIVADO DE HEXAHIDROINDENOPIRIDINA Y OCTAHIDROBENZOQUINOLINA DE FORMULA (I), DONDE R1 ES FENILO, NAFTILO, PIRROLILO, FURANILO, TIENILO, ENTRE OTROS； R2 ES H, HALOGENO, CIANO, NITRO, AMINO, ENTRE OTROS； R3 Y R4 SON H, HALOGENO, ALQUILO C1-C3, TRIFLUOROMETILO, HIDROXI, ALQUILOXI C1-C3, ENTRE OTROS； m ES 0 O 1. SON COMPUESTOS PREFERIDOS: (1H-BENZOIMIDAZOL-5-IL)-(cis-2,3,4a,5,6,10b-HEXAHIDRO-1H-BENZO[f]QUINOLIN-4-IL)-METANONA, (1H-BENZOIMIDAZOL-5-IL)-(cis-7-HIDROXI-2,3,4a,5,6,10b-HEXAHIDRO-1H-BENZO[f]QUINOLIN-4-IL)-METANONA, ACIDO cis-4-(1H-BENZOIMIDAZOL-5-CARBONIL)-1,2,3,4,4a,5,6,10b-OCTAHIDRO-BENZO[f]QUINOLINA-8-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA 11-BETA-HIDROXIESTEROIDE DESHIDROGENASA 1 (HSD 1) Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS METABOLICOS TALES COMO DIABETES TIPO 2, OBESIDAD, DISLIPIDEMIAS, ENTRE OTROS
