Referring to a hexahidroindenopiridina and octahidrobenzoquinolina Derivative of formula (i), wherein R1 is phenyl, naphthyl, pirrolilo, furanilo, tienilo, among others R2 is H, halogen, Nitro, cyano, amino, among others R3 and R4 are h, halogen, alkyl of C1 - C3, trifluoromethyl, Hydroxy, alquiloxi C1 - C3 Among others M is 0 OR 1.Preferred compounds are: (1h served - 5 - (IL) - cis - 2,3,4a, 5,6,10b - hexahidro - 1H benzo [f] quinolin-1 IL - 4 - (1H) - methanone, served - 5 - (IL) - cis - 7 Hydroxy 2,3,4a, 5,6,10b - hexahidro - 1H benzo [f] quinolin-1 - 4-yl) methanone, acid cis-4 - (1H - served - 5 - carbonyl) - 1,2,3,4,4a, 5,6,10b - octahidro - benzo [f]. Nolina - 8 - carboxylic acid, among others. It also relates to a Pharmaceutical composition.These compounds inhibit the 11 beta hydroxysteroid dehydrogenase (HSD) and are useful in the treatment of Metabolic Disorders such as type 2 diabetes, obesity, dyslipidemia, among othersREFERIDA A UN DERIVADO DE HEXAHIDROINDENOPIRIDINA Y OCTAHIDROBENZOQUINOLINA DE FORMULA (I), DONDE R1 ES FENILO, NAFTILO, PIRROLILO, FURANILO, TIENILO, ENTRE OTROS R2 ES H, HALOGENO, CIANO, NITRO, AMINO, ENTRE OTROS R3 Y R4 SON H, HALOGENO, ALQUILO C1-C3, TRIFLUOROMETILO, HIDROXI, ALQUILOXI C1-C3, ENTRE OTROS m ES 0 O 1. SON COMPUESTOS PREFERIDOS: (1H-BENZOIMIDAZOL-5-IL)-(cis-2,3,4a,5,6,10b-HEXAHIDRO-1H-BENZO[f]QUINOLIN-4-IL)-METANONA, (1H-BENZOIMIDAZOL-5-IL)-(cis-7-HIDROXI-2,3,4a,5,6,10b-HEXAHIDRO-1H-BENZO[f]QUINOLIN-4-IL)-METANONA, ACIDO cis-4-(1H-BENZOIMIDAZOL-5-CARBONIL)-1,2,3,4,4a,5,6,10b-OCTAHIDRO-BENZO[f]QUINOLINA-8-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA 11-BETA-HIDROXIESTEROIDE DESHIDROGENASA 1 (HSD 1) Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS METABOLICOS TALES COMO DIABETES TIPO 2, OBESIDAD, DISLIPIDEMIAS, ENTRE OTROS
