Relating to compounds of formula (i), where a is - or or - CH2 - n is 0 OR 1 r1 is alkyl or haloalquilo C1 C1 - 6 - 6 R2 is H, cyano, halogeno, cyano, among others R5 and R6 are independently heterociclilo cycloalkyl, aryl, heteroaryl, C1 - C3 - 6 6 alkyl, optionally substituted, among others.Preferred compounds are: 6 - (3,5-dichlorophenyl) - 5 - 4,2\ufffd chroman - methylspiro [] - 4th - imidazole Amine n - (4th - amino - 5 - methyl imidazole 4,2\ufffd chromane - spiro [] - 6 - il) - 5 - Chloro - pyridine - 2 - carboxamide among others. Also referred to a Pharmaceutical composition.These compounds are inhibitors of the beta secretase, being useful for the treatment of the disease of Alzheimers disease, senile dementia, Cerebral hemorrhage Hereditary Memory lossREFERIDO A COMPUESTOS DE FORMULA (I), DONDE: A ES -O- O -CH2- n ES 0 O 1 R1 ES ALQUILO C1-6 O HALOALQUILO C1-6 R2 ES H, CIANO, HALOGENO, CIANO, ENTRE OTROS R5 Y R6 SON INDEPENDIENTEMENTE HETEROCICLILO, ARILO, HETEROARILO, CICLOALQUILO C3-6, ALQUILO C1-6 OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-(3,5-DICLOROFENIL)-5�-METILESPIRO[CROMAN-4,2�-IMIDAZOL]-4�-AMINA N-(4�-AMINO-5�-METIL-ESPIRO[CROMANO-4,2�-IMIDAZOL]-6-IL)-5-CLORO-PIRIDINA-2-CARBOXAMIDA ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA BETA-SECRETASA, SIENDO UTILES PARA EL TRATAMIENTO DEL MAL DEL ALZHEIMER, DEMENCIA SENIL, HEMORRAGIA CEREBRAL HEREDITARIA, PERDIDA DE MEMORIA
