NABUURS, SANDER BERNARDUS,CALS, JOSEPH MARIA GERARDUS BARBARA
申请号：
PE2016000733
公开号：
PE20160891A1
申请日:
2014.12.03
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
The invention refers to a formula compound, wherein a11, A12, A13 and A14 are n or cr11, Cr12, Cr13 and cr14 respectively； R1 is liquid crystal tar such as C1-C6, cycloquilo C3-C6； R2 and R3 are h, F, etc.； R4 is h or C1-C6 tar； R5 is h, hydroxietilo, etc.； R6, R7, R8, R9, R10, R11, R12, R13 and 14 are genoh, Among others, R15 and R16 are h, C1-C6 tar, etc. The preferred compounds are: n - (4 - (1,1,3,3,3-hexafluoro-2-hydroxypropane-2-one) phenyl) - 2 - (4 - (methylsulfur) phenyl)； 2 - (4 - (ethylsulfonyl) phenyl) - N - (4 - (1,1,3,3-hexafluoro-2-hydroxypropane-2-one) phenyl.There are others He also mentioned a pharmaceutical composer These compounds are gamma compass inhibitors that can be used to treat autoimmune diseases and inflammation.La presente invencion se refiere a compuestos de Formula I donde A11, A12, A13 y A14 son N o CR11, CR12, CR13, CR14, respectivamente； R1 es alquilo C1-C6, cicloalquilo C3-C6, entre otros； R2 y R3 son H, F, entre otros； R4 es H o alquilo C1-C6； R5 es H, hidroxietilo, entre otros； R6, R7, R8, R9, R10, R11, R12, R13 y R14 son H, halogeno, entre otros； R15 y R16 son H, alquilo C1-C6, entre otros. Son compuestos preferidos: N-(4-(1,1,1,3,3,3-hexafluoro-2-hidroxipropan-2-il)fenil)-2-(4-(metilsulfonil)fenil)acetamida； 2-(4-(etilsulfonil)fenil)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hidroxipropan-2-il)fenil)acetamida； entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son inhibidores de ROR gamma y son utiles en el tratamiento de enfermedades autoinmunes y enfermedades inflamatorias
