Adaptive inflatable cushion (1), in particular designed to be located at the base of a seat or seating area, comprising a flexible main base (2) having a plurality of inflatable cells (3), arranged in a matrix that protrudes in an upward direction, and inflating means, including pressure regulating means operated by a programmable control unit that is associated with inflating means, such that a plurality of separate regions each defined by one or more inflatable cells having pressure values equal to or different from each other are defined in the flexible main base (2). In this way, this element can prevent the formation of pressure ulcers in users with spinal cord injuries, limited mobility and/or professionals who must spend long periods of time in a static seated position.