Jeffrey A. Bacha,Dennis Brown,Sandra Dunn,Anne Steinø
申请号：
US14245738
公开号：
US20140221442A1
申请日:
2014.04.04
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide； the drug acts independently of the MGMT repair mechanism.
