Bacha, Jeffrey A.,Brown, Dennis M.,Steino, Anne,Fouse, Shaun
申请号：
AU2015346598
公开号：
AU2015346598A1
申请日:
2015.11.10
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and for the treatment of glioblastoma multiforme (GBM). Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide； the drug acts independently of the MGMT repair mechanism.
