UTILISATION DE DIANHYDROGALACTITOL ET DE LEURS ANALOGUES OU DERIVES DANS LE TRAITEMENT DU CARCINOME NON A PETITES CELLULES DES POUMONS ET DU CANCER DES OVAIRES

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专利权人:

DEL MAR PHARMACEUTICALS

发明人:

BACHA, JEFFREY A.,BROWN, DENNIS M.,STEINO, ANNE

申请号：

CA2946538

公开号：

CA2946538A1

申请日:

2015.04.06

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and ovarian cancer. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide, cisplatin, and thymidine kinase inhibitors； the drug acts independently of the MGMT repair mechanism. Dianhydrogalactitol can be used together with other anti-neoplastic agents and can possess additive or super-additive effects.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/