UTILISATION D'HEXITOLS SUBSTITUES, Y COMPRIS LE DIANHYDROGALACTITOL ET SES ANALOGUES, POUR LE TRAITEMENT DE CELLULES SOUCHES DE MALADIES NEOPLASIQUES ET DE CANCERS, Y COMPRIS LE GLIOBLASTOME MULTIFORME ET LE MEDULLOBLASTOME

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专利权人:

DENNIS;BROWN

发明人:

BROWN, DENNIS,BACHA, JEFFREY,DUNN, SANDRA

申请号：

CA2862706

公开号：

CA2862706A1

申请日:

2013.01.22

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide； the drug acts independently of the MGMT repair mechanism.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/