THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;KIM, SUNG HOON;KATZENELLENBOGEN, BENITA;MADAK-ERDOGAN, ZEYNEP;THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER;KATZENELLENBOGEN, JOHN;SHAUL, PHIL
发明人:
KATZENELLENBOGEN, JOHN,KATZENELLENBOGEN, BENITA,KIM, SUNG HOON,MADAK-ERDOGAN, ZEYNEP,SHAUL, PHILIP
申请号：
CA3010506
公开号：
CA3010506A1
申请日:
2017.01.06
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.
