ФЕРГЮСОН Марк Уильям Джеймс (GB),О'КЕЙН Шэрон (GB),МЕЙСОН Трейси (GB),КУПЕР Марк (GB),ОККЛСТОН Ник (GB),ФЭЙРЛЭМБ Дэвид (GB),БУШ Джеймс (GB),ОКЕЙН Шэрон (GB)
申请号:
RU2010128451/15
公开号:
RU2010128451A
申请日:
2008.12.11
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method of suppressing scarring that occurs during wound healing in a person, comprising treating that part of the body on which it is necessary to suppress scarring, in which, at the first treatment session, delivery is made to every centimeter of the wound edge or to every centimeter of the site where the wound will be formed, from about 350 to 1000 ng TGF-β3, and in the second treatment session, carried out 8-48 hours after the first treatment session, TGF-β3 is delivered to the specified wound in an amount of about 350 to 1000 ng per centimeter of the edge of the pa s, which is necessary to suppress the scarring. ! 2. The method according to claim 1, in which TGF-β3 is delivered by local injection. ! 3. The method according to claim 2, in which the first treatment session is carried out in the area where the wound should be formed, while the local injection is administered essentially along the midline of the future wound. ! 4. The method according to claim 2, in which the first treatment session is carried out in the area where the wound should be formed, while local injection is administered on each edge of the future wound. ! 5. The method according to claim 2, in which the first and / or second treatment session is carried out along the edges of the wound, while local injection is administered at a distance of not more than 0.5 cm from the edge of the wound! 6. The method according to claim 1, in which the first and / or second treatment session includes the delivery of TGF-β3 to the site, leaving at least half a centimeter for each end of the wound. ! 7. A method of suppressing scarring that occurs during wound healing in a person, comprising treating that part of the body in which it is necessary to suppress scarring, in which, from the first treatment session, delivery is made from about 350 ng to 1000 for every centimeter of the body in which the wound is formed1. Способ подавления рубцевания, возникающего при заживлении раны у человека, включающий л