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Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine d3 receptor
专利权人:
ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人:
HAUPT ANDREAS
申请号:
NZ63028113
公开号:
NZ630281A
申请日:
2013.10.21
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
The present disclosure relates to acylaminocycloalkyl compounds of the formula (I) as described herein and to their salts and N-oxides. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor. In formula (I), the variables have the following meanings: m is 1 or 2, n is 1 or 2, A is selected from the group consisting of CH2, CH2CH2, CHFCH2 and CF2CH2, R1 is hydrogen or C1-C3-alkyl, R2 is selected from the group consisting of hydrogen, and fluorine, R3a is selected from the group consisting of hydrogen and methyl, R3b is selected from the group consisting of hydrogen and methyl, R4 is branched C4-C6 alkyl or branched fluorinated C4-C6 alkyl, and R5 is an oxygen containing radical such as C1-C2-alkoxy-C1-C4-alkyl, fluorinated C1-C2-alkoxy-C1-C4-alkyl, hydroxy-C1-C4-alkyl, fluorinated hydroxy-C1-C4-alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, fluorinated C3-C5 cycloalkyl, C3-C5 cycloalkoxy-C1-C4-alkyl and fluorinated C3-C5 cycloalkoxy-C1-C4-alkyl. Examples of disease treated include: disorder or condition of the central nervous system, Parkinson&rsquos disease, schizophrenia, bipolar disorder, depression, motivation disturbances, anxiety, cognitive dysfunction, pain, disorder associated with drug abuse, eating disorders, renal function disorders and diabetic nephropathy.
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