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acylaminocycloalkyl compounds suitable for treating disorders responsive to dopamine d3 receptor modulation
专利权人:
ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人:
ANDREAS HAUPT
申请号:
BR112015008992
公开号:
BR112015008992A2
申请日:
2013.10.21
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
Summary "Suitable acylaminocycloalkyl compounds for treatment of disorders responsive to dopamine d3 receptor modulation" The present invention relates to novel acylaminocycloalkyl compounds, in particular to the compounds of formula I as described herein and to their salts and n-oxides . The compounds have valuable therapeutic properties and are suitable in particular for the treatment of diseases responsive to dopamine d3 receptor modulation. in formula i, the variables have the following meanings: m is 1 or 2, n is 1 or 2, a is selected from the group consisting of ch2, ch2ch2, chfch2 and cf2ch2, r1 is hydrogen or c1-c3-alkyl , r2 is selected from the group consisting of hydrogen and fluorine, r3a is selected from the group consisting of hydrogen and methyl, r3b is selected from the group consisting of hydrogen and methyl, r4 is c4-c6 branched or C4-C6 fluorinated branched alkyl, and R5 is an oxygen-containing radical, such as C1-C2-alkoxy-C1-C4-alkyl, C1-C2-alkoxy-C1-C4-alkyloxy, hydroxy-C1 C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C4-C8-C4-C4-C4-C4-C4-C4-C4-cycloalkoxy fluorinated alkyl.resumo “compostos de acilaminocicloalquila adequados para tratamento de distúrbios que respondem à modulação de receptor d3 de dopamina” a presente invenção refere-se a novos compostos de acilaminocicloalquila, em particular aos compostos da fórmula i como aqui descritos e a seus sais e n-óxidos. os compostos possuem propriedades terapêuticas valiosas e são adequa-dos, em particular, para o tratamento de doenças que respondem à modulação do receptor d3 de dopamina. na fórmula i, as variáveis têm os seguintes significados: m é 1 ou 2, n é 1 ou 2, a é selecionado a partir do grupo que consiste em ch2, ch2ch2, chfch2 e cf2ch2, r1 é hidrogênio ou c1-c3-alquila, r2 é selecionado a partir do grupo que consiste em hidrogênio e flúor, r3a é selecionado a partir do gru-po que consiste em hidrogênio
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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