Compositions and methods for preventing or treating obesity are described. Compositions include an extract of green tea, an extract ofGynostemma, and optionally, an extract of unripe apple, wherein the extract of green tea and the extract ofGynostemmasynergistically inhibit the activity of Sterol Regulatory Element Binding Protein 1c (SREBP1c) promoter, and wherein the extract of green tea, the extract ofGynostemma, and the extract of unripe apple inhibit IL-1beta stimulated Nuclear Factor Kappa-Light-Chain-enhancer of activated B cells (NF-κB) activity.用於預防或治療肥胖的組成物和方法被描述。組成物包括一綠茶的萃取物、一絞股藍屬的萃取物和選擇性地一未成熟的蘋果的萃取物,其中該綠茶的萃取物和該絞股藍屬的萃取物協同地抑制固醇調節元件結合蛋白1c (SREBP1c)啟動子的活性,以及其中該綠茶的萃取物、該絞股藍屬的萃取物和該未成熟的蘋果的萃取物抑制經IL-1β刺激的核因子活化B細胞κ輕鏈增強子(NF-κB)活性。(無)
