ALBAUGH, PAMELA A.,CHOI, HA-SOON,CHOPIUK, GREGORY,FAN, YI,RUCKER, PAUL VINCENT,WANG, ZHICHENG
申请号：
ES09747213
公开号：
ES2548135T3
申请日:
2009.05.07
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of Formula (I), a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate thereof: ** Formula ** where: R1 is where, X1 and X2 are both N and X3 and X4 are both C k is 1, 2 or 3； each R3 is phenyl optionally substituted with 1 to 3 substituents independently selected from halogen, alkyl of 1 to 8 carbon atoms and alkyl of 1 to 8 carbon atoms substituted with halogen； R2 is aryl of 6 to 14 carbon atoms, heteroaryl of 2 to 13 carbon atoms or heterocycloalkyl of 2 to 14 carbon atoms, wherein aryl of 6 to 14 carbon atoms, heteroaryl of 2 to 13 carbon atoms or heterocycloalkyl of 2 to 14 carbon atoms of R2 are optionally substituted with 1 to 3 substituents independently selected from halogen, heterocycloalkyl of 2 to 14 carbon atoms, heteroaryl of 2 to 13 carbon atoms, alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, -CN, -C (O) N (R4) 2, - N (R4) C (O) OR4, -N (R4) C (O) R4, -C (O) R9, -OR9, -C (O) OR9, -N (R4) 2, -R6, -OR6, -L1R5, -L1R6, -Y1R5, -Y1R6, -S (O) 2R9, - S (O) 2N (R4) 2, -NR4S (O) 2R4, -OC (O) R9, alkoxy of 1 to 8 carbon atoms, hydroxylalkyl of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms substituted with halogen and alkoxy 1 to 8 carbon atoms substituted with halogen； each R4 is independently selected from H, alkyl of 1 to 8 carbon atoms, -L1R5, -L1R6, -L1R8, heteroaryl of 2 to 13 carbon atoms, aryl of 6 to 14 carbon atoms, heterocycloalkyl of 2 to 14 atoms carbon and cycloalkyl of 3 to 8 carbon atoms, wherein the alkyl of 1 to 8 carbon atoms, heteroaryl of 2 to 13 carbon atoms and cycloalkyl of 3 to 8 carbon atoms are optionally substituted with 1 to 3 substituents independently selected from halogen, deuterium, -CD3, -S (O) 2R9, -CN, alkyl of 1 to 8 carbon atoms, - OR9, -N (R9) 2 and - (CH2) pOR9； L1 is a bond, alkylene of 1 to 8 carbon atoms, alkenylene of 2 to 8 carbon atoms, -O (CH2) p-, -C (O) -, - N (R9) -, (CH2) pC ( O) -, -C (O) (CH2) pO (CH2) p- or -C (O) O-； Y1 is arylene of 6 to 14 carbon atoms, h
