BAETTIG, URS,BALA, KAMLESH JAGDIS,BUDD, EMMA,EDWARDS, LEE,HOWSHAM, CATHERINE,HUGHES, GLYN,LEGRAND, DARREN MARK,SPIEGEL, KATRIN
申请号：
ES11708490
公开号：
ES2552503T3
申请日:
2011.03.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula I: ** Formula ** or pharmaceutically acceptable salts thereof, wherein: A is N or CR4a； R1 is H； alkyl of 1 to 8 carbon atoms optionally substituted with one or more halogen atoms； alkenyl of 2 to 8 carbon atoms； alkynyl of 2 to 8 carbon atoms； cycloalkyl of 3 to 10 carbon atoms； cycloalkenyl of 5 to 10 carbon atoms； -alkyl of 1 to 4 carbon atoms -cycloalkyl of 3 to 8 carbon atoms； alkoxy of 1 to 8 carbon atoms optionally substituted with one or more halogen atoms； halogen； SO2NR8R9； SO2R10； S-alkyl of 1 to 8 carbon atoms optionally substituted with one or more halogen atoms； S-aryl of 6 to 14 carbon atoms； CN； NR11R12； C (O) NR13R14； NR13SO2R15； NR13C (O) R15, CO2R15, - (alkyl of 0 to 4 carbon atoms) -aryl of 6 to 14 carbon atoms； or - (alkyl of 0 to 4 carbon atoms) - heterocyclic group of 3 to 14 members, wherein the heterocyclic group contains at least one heteroatom selected from N, O and S； wherein the cycloalkyl, cycloalkenyl, aryl, and heterocyclyl groups are each optionally substituted with one or more Z substituents； R2 is halo-alkyl of 1 to 4 carbon atoms； R3 and R4a are each independently H or alkyl of 1 to 8 carbon atoms optionally substituted with one or more halogen atoms； R4 is H, or alkyl of 1 to 8 carbon atoms optionally substituted with one or more halogen atoms； R5 is - (CH2) m-NR17R18, - (CH2) m-OR '； alkoxy of 1 to 8 carbon atoms optionally substituted with one or more halogen atoms； - (alkyl of 0 to 4 carbon atoms) -CO2R15； - (alkyl of 0 to 4 carbon atoms) -aryl of 6 to 14 carbon atoms or - heterocyclic group of 3 to 14 members, wherein the heterocyclic group contains at least one heteroatom selected from N, O and S； wherein the - (alkyl of 0 to 4 carbon atoms) - aryl of 6 to 14 carbon atoms, and - (alkyl of 0 to 4 carbon atoms) - heterocyclic group of 3 to 14 members, are each optionally substituted with one or more substituents Z； R6 is alkyl of 1 to 8 carbon atoms optionally substituted with one or more halogen atom
