The present invention is related to a compound represented by formula (I)wherein R1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, or the like X is -N(R3)-, -O-, or -S- Y is =C(R4)-, or =N- Z is -N(R7)-, -O-, or -S-R2 is substituted or unsubstituted alkyloxy, or the like, or a group represented by the following formula: -(CR2aR2b)n-R2c, wherein R2a is each independently a hydrogen atom, halogen, or the like R2b is each independently a hydrogen atom, halogen, or the like R2a and R2b which are attached to the same carbon atom may be taken together to form oxo, a substituted or unsubstituted non-aromatic carbocycle, or the like two of R2a which are attached to the adjacent carbon atoms and/or two of R2b which are attached to the adjacent carbon atoms may be taken together to form a bond R2c is substituted or unsubstituted aromatic carbocyclyl, or the like n is an integer from 1 to 3R3 and R7 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the likeR4 and R5 are each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the likeR6 is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like,or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.
