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Agents de liaison de récepteur nucléaire
专利权人:
Gtx; Inc.
发明人:
申请号:
EP13174659.6
公开号:
EP2647376A1
申请日:
2008.01.22
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
A compound, or its optical isomer, pharmaceutically acceptable salt, pharmaceutical product, N-oxide, hydrate or any combination thereof, represented by the structure of Formula VI:wherein R1 is hydrogen; R2 is hydrogen, COOH, -C(=NH)-OH, -CH=CH2, hydroxyl, cyano, OCOR, alkenyl, OSO2CF3, or protected hydroxyl; R3, R8 and R9 are hydrogen; R10 is hydrogen, halogen, CH=CHCO2H, CH=CHCO2R, -CH=CH2, cyano, aryl, 4-methoxyphenyl, 4-hydroxyphenyl, alkenyl, alkyl, or haloalkyl; R11 is hydrogen, halogen, cyano, or SO2R; R6 is hydrogen, halogen, or C1-C6-alkyl; R7 is hydrogen or halogen; R' is hydrogen, Alk or COR; R" is hydrogen, Alk or COR; and R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, aryl, benzyl, halogen, alkenyl, CN, or NO2; and Alk is a linear alkyl of 1-7 carbons, branched alkyl of 1-7 carbons, or cycloalkyl of 3-8 carbons; for use in treating, delaying onset, reducing the incidence of, or reducing the severity of a fatty liver condition in a subject.
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