BURKS, Heather Elizabeth,DECHANTSREITER, Michael A.,HE, Guo,NUNEZ, Jill,PEUKERT, Stefan,SPRINGER, Clayton,SUN, Yingchuan,THOMSEN, Noel Marie-France,TRIA, George Scott,YU, Bing
申请号：
ES14708992
公开号：
ES2671516T3
申请日:
2014.02.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula I: ** Formula ** wherein: n is selected from 0, 1 and 2； m is selected from 0, 1 and 2； X is selected from O and NR6； wherein R6 is alkyl of 1 to 4 carbon atoms； Y1 is selected from N and CR7； wherein R7 is selected from hydrogen and alkyl of 1 to 4 carbon atoms； R1 is hydrogen； R2 is selected from hydrogen and halogen； R3 is selected from -CH2CH2R8b and -CR8a>； = CR8aR8b； wherein each R8a is independently selected from hydrogen, fluorine and alkyl of 1 to 4 carbon atoms； and R8b is selected from -C (O) OR9a, - C (O) NR9aR9b, -C (O) NHOR9a, -C (O) X2R9a and a 5- to 6-membered heteroaryl selected from: ** Formula ** where the dotted line indicates the junction point with -CH2CH2 or -CR8a>； = CR8a of R3； wherein X2 is alkylene of 1 to 4 carbon atoms； R9a and R9b are independently selected from hydrogen, alkyl of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms substituted by hydroxyl, alkyl of 1 to 4 carbon atoms substituted by halogen and -X4R10； wherein X4 is selected from a bond and alkylene of 1 to 3 carbon atoms； and R10 is a saturated 4 to 6 member ring containing 1 to 3 atoms independently selected from O, N and S； wherein the heteroaryl of R8b is unsubstituted or substituted with 1 to 3 groups independently selected from alkyl of 1 to 4 carbon atoms, and cycloalkyl of 3 to 8 carbon atoms； R4 is selected from hydrogen, alkyl of 1 to 4 carbon atoms, halogen and alkoxy of 1 to 3 carbon atoms； R5 is selected from aryl of 6 to 10 carbon atoms, and a 5- to 6-membered heteroaryl selected from: ** Formula ** wherein the dotted line indicates the point of attachment to the benzothiophene core； wherein this aryl of 6 to 10 carbon atoms, or heteroaryl of R5 is substituted with 1 to 3 groups selected from -X3-R5a and R5a； wherein X3 is methylene； R5a is selected from hydroxyl, amino, alkyl of 1 to 4 carbon atoms, halogen, nitro, cyano, alkyl of 1 to 4 carbon atoms substituted by halogen, alkyl of 1 to 4 carbon atoms substituted by cyano, alk
