GRIFFIOEN, Gerard,VAN DOOREN, Tom,ROJAS DE LA PARRA, Veronica,MARCHAND, Arnaud,ALLASIA, Sara,KILONDA, Amuri,CHALTIN, Patrick
申请号：
ES10728150
公开号：
ES2627957T3
申请日:
2010.06.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (AA1) or a stereoisomer, enantiomer or tautomer thereof, ** Formula ** in which - each dotted line individually represents an optional double bond, in which at most two selected dotted lines of the five dotted lines are a double link； - E1 is independently selected from CR1； and N； - E2 is independently selected from NR2； I； - E3 is independently selected from CR3； and N； - Q is independently selected from NRb-C (O)； and C (O) NH； - Ra is hydrogen or can be taken together with Rb to form a substituted or unsubstituted 4, 5, 6, 7 or 8-membered ring containing an N atom； - Rb is hydrogen or can be taken together with Ra to form a substituted or unsubstituted 4, 5, 6, 7 or 8-membered ring containing an N atom； - each R1, R3, R4 and R6 is independently selected from hydrogen； halogen； -OH； -OR10； -SH； -SR10； -S (O) R11； -S (O) 2R11； -SO2NR12R13； trifluoromethyl； trifluoromethoxy； nitro； -NHC (O) R10； -NHS (O) 2R10； - NHC (O) NR12R13； -NR10C (O) R10； -NR10S (O) 2R10； -NR10C (O) NR12R13； -NR12R13； -ciano -COOH； -COOR10； - C (O) NR12R13； -C (O) R11； I rent； alkenyl； alkynyl； aryl； heterocycle； arylalkylene； arylalkenylene； arylalkylene； heterocycle-alkylene； heterocycle-alkenylene； heterocycloalkynylene； * and wherein said alkyl, alkenyl, alkynyl, aryl, heterocycle, arylalkylene, arylalkenylene, arylalkylene, heterocycle-alkylene, heterocyclo-alkenylene or heterocyclo-alkynylene optionally includes one or more heteroatoms in the alkyl (eno) moiety, alkenyl (eno ) or alkynyl (eno), said heteroatoms being selected from the atoms O, S and N； * and wherein said alkyl, alkenyl, alkynyl, aryl, heterocycle, arylalkylene, arylalkenylene, arylalkylene, heterocycle-alkylene, heterocyclo-alkenylene or heterocyclo-alkynylene may be unsubstituted or substituted with Z； * and wherein a carbon atom or hetero atom of said alkyl, alkenyl, alkynyl, aryl, heterocycle, arylalkylene, arylalkenylene, arylalkylene, heterocycle-alkylene, heterocyclo-alkenylene or heterocyclo
